The best Side of ceesdekker
The best Side of ceesdekker
Blog Article
‘Sure, that may be about proper. I try to find a Bodily comprehension of biological techniques in a very bottom-up way. I believe you could potentially distinguish three traces of exploration in my team at this time. The initial problems chromosome composition: How can you get yourself a metre-very long DNA polymer folded and organised in this type of microscopic mobile? Now we have created visualisation tactics that enable us to study how, by way of example, SMC proteins loop DNA (movie on Youtube) in order to Construct up chromosomes.
Our group scientific tests bacterial mobile division and it is aiming to represent a ‘bottom up biology’ in synthetic cells that will autonomously divide. Our principal curiosity lies in cell division, chromatin composition, and spatial Regulate.
, Groningen researchers current the outcome of their efforts to produce labs additional sustainable and provide techniques for other labs.
Unfortunately, for years just after Iijima’s report, the manufacture of clean nanotubes was cumbersome. In 1996, on the other hand, the group of Richard Smalley at Rice College managed to produce solitary-walled carbon nanotubes at high produce. Soon following, I contacted Smalley, and we chose to join forces to measure the transportation via a single carbon nanotube.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping
Microbiology has only been around for the century, because we started to research micro-organisms a lot more severely. I assumed nanobiology was an correct term, because all molecular biological related interactions take place in the nanoscale: a protein is several nanometres in dimension, DNA is 2 nm thick.’
All parameters had been the exact same for every panel in this video, except for the Preliminary placement on the 6hb rod (demonstrated in blue) to the nanopore. Simulations that terminated early as a consequence of translocation of the rod with the pore are marked by a grey track record.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.
The rotors harness Vitality from a nanoscale drinking water and ion movement that's created by a static chemical or electrochemical opportunity gradient from the nanopore, which might be recognized via a salt gradient or applied voltage, respectively. These synthetic cees dekker nanoengines self-Arrange and operate autonomously in physiological disorders, suggesting solutions to constructing energy-transducing motors at nanoscale interfaces.
It absolutely was during this period that Dekker completed exploration on magnetic spin units and on sounds in superconductors and semiconductors.
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
Lots of new phenomena ended up identified, and he and his study team proven a leading situation On this field of investigate. Dekker and his investigation group identified new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor dependant on an individual nanotube molecule.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
Last but not least, I'll briefly sketch several of our Thoughts to explore the building of synthetic cells, specifically our initial actions to establish synthetic cell division.